Table of Contents
- The Two-Step Filler Process
- Step One: Hyaluronic Acid Filler Placement
- Step Two: PRP Activation
- Which Hyaluronic Acid Fillers Work Best?
- Juvederm Voluma
- Juvederm Vollure or Volbella
- Restylane Lyft
- Restylane Refyne or Defyne
- Why Hyaluronic Acid Specifically?
- What About the PRP Component?
- How Filler Choice Affects Your Results
- The Bottom Line

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The Vampire Facelift is not just PRP alone. This treatment combines platelet-rich plasma from your own blood with hyaluronic acid dermal fillers to create both immediate volume and long-term collagen stimulation. Understanding which fillers work best and why they matter can help you make an informed decision about your facial rejuvenation.
The Two-Step Filler Process
A true Vampire Facelift follows a specific protocol that requires FDA-approved dermal fillers as the foundation. The filler creates structural support and shape, while the PRP activates stem cells and promotes natural collagen growth over time.
Step One: Hyaluronic Acid Filler Placement
The first phase involves strategically injecting hyaluronic acid filler into specific areas of the face. This creates the scaffolding that defines your facial contours. At North Star Medical, we use premium FDA-approved fillers like Juvederm or Restylane, chosen based on your unique facial anatomy and aesthetic goals.
These fillers immediately restore volume to areas that have lost fullness due to aging. Think of this as the architectural phase where we rebuild the structure of your face.
Step Two: PRP Activation
After the filler placement, your own platelet-rich plasma is injected into and around the treated areas. The growth factors in your PRP work to stimulate collagen production, improve skin texture, and create a natural glow. This is where the regenerative magic happens.

Which Hyaluronic Acid Fillers Work Best?
Not all fillers perform equally in a Vampire Facelift. The ideal filler must have specific characteristics to work synergistically with PRP.
Juvederm Voluma
This filler excels at restoring midface volume and cheek projection. Its thick, cohesive gel structure makes it perfect for creating the lifting effect that defines the Vampire Facelift. Voluma can last up to two years, making it a cost-effective choice for the structural component.
Juvederm Vollure or Volbella
For treating fine lines around the mouth and eyes, these softer formulations integrate smoothly with PRP. They create natural-looking results without the stiffness that some patients worry about.
Restylane Lyft
Another excellent option for cheek augmentation and midface lifting. Its unique cross-linking technology provides firm support while allowing natural facial movement. Some patients prefer Restylane over Juvederm due to differences in texture and longevity.
Restylane Refyne or Defyne
These flexible fillers work well in areas that require more movement, like the nasolabial folds. When combined with PRP, they soften deep lines while maintaining natural facial expressions.
Why Hyaluronic Acid Specifically?
Hyaluronic acid is the only filler type recommended for the Vampire Facelift procedure. Here's why other filler types do not work.
Hyaluronic acid is naturally found in your skin and holds up to 1,000 times its weight in water. This hydration property complements the regenerative effects of PRP beautifully. Your body recognizes it as a natural substance, which reduces the risk of adverse reactions.
Other filler types like calcium hydroxylapatite or poly-L-lactic acid stimulate collagen on their own, which can create unpredictable results when combined with PRP. Hyaluronic acid provides pure volume without interfering with the biological processes PRP triggers.
Additionally, hyaluronic acid fillers can be dissolved with hyaluronidase if needed. This safety feature gives both patients and practitioners peace of mind.
What About the PRP Component?
While the filler brands vary based on patient needs, the PRP used in your Vampire Facelift comes from your own blood. At North Star Medical, we draw a small amount of blood and process it using medical-grade centrifugation to concentrate the platelets and growth factors.
The PRP concentration matters significantly. Higher platelet counts deliver more growth factors, which means better collagen stimulation and longer-lasting results. We use a dual-spin centrifugation method to achieve platelet concentrations that are three to five times higher than your baseline blood levels.
How Filler Choice Affects Your Results
The specific filler selected for your treatment depends on several factors: your facial anatomy, the degree of volume loss, your skin quality, and your aesthetic goals. During your consultation at North Star Medical in St. Paul, we assess these factors to create a customized treatment plan.
Some patients need more structural support in the cheeks and require a firmer filler like Voluma. Others have good bone structure but need subtle smoothing, making Vollure a better choice. The key is matching the right filler density and placement to your unique needs.
The Bottom Line
The Vampire Facelift uses FDA-approved hyaluronic acid fillers combined with your own PRP. This dual approach creates immediate volume restoration plus long-term regenerative benefits that improve over several months. The specific filler brand matters less than the expertise of the injector and the quality of the PRP preparation.
